Characterization of a Peptide Domain within the GB Virus C NS5A Phosphoprotein that Inhibits HIV Replication

@article{Xiang2008CharacterizationOA,
  title={Characterization of a Peptide Domain within the GB Virus C NS5A Phosphoprotein that Inhibits HIV Replication},
  author={Jinhua Xiang and James H. McLinden and Qing Chang and Emma L. Jordan and Jack T. Stapleton},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={197 - 207}
}
BACKGROUND GBV-C infection is associated with prolonged survival in HIV-infected people and GBV-C inhibits HIV replication in co-infection models. Expression of the GBV-C nonstructural phosphoprotein 5A (NS5A) decreases surface levels of the HIV co-receptor CXCR4, induces the release of SDF-1 and inhibits HIV replication in Jurkat CD4+ T cell lines. METHODOLOGY/PRINCIPAL FINDINGS Jurkat cell lines stably expressing NS5A protein and peptides were generated and HIV replication in these cell… CONTINUE READING

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Highly Influenced

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