Corpus ID: 83174976

Characterization of a Novel Tetraspanin-Rich, HIV-1-Containing Compartment in Dendritic Cells

@inproceedings{Garcia2008CharacterizationOA,
  title={Characterization of a Novel Tetraspanin-Rich, HIV-1-Containing Compartment in Dendritic Cells},
  author={Eduardo Garcia},
  year={2008}
}
Dendritic cells (DC) are crucial components of the early events of HIV infection. DC capture and internalize HIV-1 at mucosal surfaces and efficiently transfer, in the absence of viral replication in DC, the virus to CD4+ T cells through infectious synapses (trans-infection pathway). Alternatively, HIV-1 replicates in DC, the resulting DC-T cell viral transfer resulting exclusively from de novo produced viral particles in infected DC (cis-infection pathway). Our results clearly indicate that… Expand

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