Characterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania major

@inproceedings{Aoki2016CharacterizationOA,
  title={Characterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania major},
  author={Juliana Ide Aoki and Adriano Cappellazzo Coelho and Sandra M{\'a}rcia Muxel and Ricardo Andrade Zampieri and Eduardo Milton Ramos Sanchez and Audun Helge Nerland and Lucile Maria Floeter-Winter and Paulo Cesar Cotrim},
  booktitle={PLoS neglected tropical diseases},
  year={2016}
}
BACKGROUND Tubercidin (TUB) is a toxic adenosine analog with potential antiparasitic activity against Leishmania, with mechanism of action and resistance that are not completely understood. For understanding the mechanisms of action and identifying the potential metabolic pathways affected by this drug, we employed in this study an overexpression/selection… CONTINUE READING