Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence.

@article{Dey2010CharacterizationOA,
  title={Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence.},
  author={R. Bhatia Dey and Claudio Meneses and Poonam Salotra and Shaden Kamhawi and Hira Lal Nakhasi and R Duncan},
  journal={Molecular microbiology},
  year={2010},
  volume={77 2},
  pages={399-414}
}
Leishmaniasis is caused by the dimorphic protozoan parasite Leishmania. Differentiation of the insect form, promastigotes, to the vertebrate form, amastigotes, and survival inside the vertebrate host accompanies a drastic metabolic shift. We describe a gene first identified in amastigotes that is essential for survival inside the host. Gene expression analysis identified a 27 kDa protein-encoding gene (Ldp27) that was more abundantly expressed in amastigotes and metacyclic promastigotes than in… CONTINUE READING
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