Characterization of a Labile Naloxone Binding Site (λ Site) in Rat Brain

@article{Grevel1985CharacterizationOA,
  title={Characterization of a Labile Naloxone Binding Site ($\lambda$ Site) in Rat Brain},
  author={Joachim Grevel and Victor C. Yu and Wolfgang Sadee},
  journal={Journal of Neurochemistry},
  year={1985},
  volume={44}
}
Abstract: A high‐affinity binding site selective for naloxone and other 4,5‐epoxymorphinans (λ site) has been previously described in rat brain. Following homogenization of freshly dissected brain, the λ sites convert from a high‐affinity to a low‐affinity state. When measured with [3H]naloxone, the decay is very rapid at 20°C (t1/2 < 2 min), whereas it is progressively slowed at lower temperatures. Proteinase inhibitors, antoxidants, and sulfhydryl group‐protecting agents failed to prevent… 
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