Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Strain in a Patient with Endocarditis

@article{Julian2007CharacterizationOA,
  title={Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Strain in a Patient with Endocarditis},
  author={K. Julian and K. Kosowska-Shick and C. Whitener and M. Roos and H. Labischinski and A. Rubio and L. Parent and L. Ednie and L. Koeth and T. Bogdanovich and P. Appelbaum},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2007},
  volume={51},
  pages={3445 - 3448}
}
ABSTRACT We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene. 
Daptomycin-nonsusceptible, vancomycin-intermediate, methicillin-resistant Staphylococcus aureus endocarditis.
TLDR
The present report describes the first Canadian case of daptomycin-nonsusceptible, vancomycin-intermediate S aureus infection. Expand
Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains
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A correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility was observed and there were no detectable fitness differences between strains in experimental infective endocarditis. Expand
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Multiple gene contribution to the phenotypic and genotypic Daptomycin non-susceptible (DNS) variants of Methicillin-Resistant Staphylococcus aureus isogenic strains
TLDR
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