Characterization of a Cathelicidin from the Colubrinae Snake, Sinonatrix annularis

  title={Characterization of a Cathelicidin from the Colubrinae Snake, Sinonatrix annularis},
  author={Aili Wang and Fen Zhang and Zhi-lai Guo and Yan Ling Chen and Minghui Zhang and Haining Yu and Yipeng Wang},
  journal={Zoological Science},
  pages={68 - 76}
The cathelicidins represent an important family of host defense peptides (HDPs) found exclusively in vertebrates, which serve as a critical effector in host immune response against microbial infections. To date, a large number of cathelicidins has been identified from diverse vertebrates, such as mammals, birds, reptiles, amphibians and fishes. Sixteen cathelicidins have been identified from snakes in the Elapidae, Viperidae, and Biodae families. However, no cathelicidin has been discovered… Expand
3 Citations
Pseudonajide peptide derived from snake venom alters cell envelope integrity interfering on biofilm formation in Staphylococcus epidermidis
Pseudonajide is presented, which is derived from a Pseudonaja textilis venom peptide and has antimicrobial and antibiofilm activity against Staphylococcus epidermidis, and results suggest that pseud onajide’s positives charges interact with negatively charged cell wall components of S. epiderMidis, leading to cell damage and inhibiting biofilm formation. Expand
Snake Venom Cathelicidins as Natural Antimicrobial Peptides
This review will focus on natural snake venom cathelicidins as promising candidates for the development of new antibacterial agents to fight antibiotic-resistant bacteria. Expand
Hitchhiking with Nature: Snake Venom Peptides to Fight Cancer and Superbugs
The state of the art in snake venom-derived peptides and their therapeutic applications are described, reinforcing the potential of snake venom components as therapeutic agents, particularly in the quest for new antimicrobial and anticancer drugs. Expand


Snake Cathelicidin from Bungarus fasciatus Is a Potent Peptide Antibiotics
Potent, broad spectrum, salt-independent antimicrobial activities make cathelicidin-BF an excellent candidate for clinical or agricultural antibiotics and discovery of snake cathe Alicidin with atypical structural and functional characterization offers new insights on the evolution of cathe Licidins. Expand
Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity and Special Mechanism*
This study demonstrates that Hc-CATH, the first cathelicidin from sea snake discovered to have both antimicrobial and anti-inflammatory activity, is a potent candidate for the development of peptide antibiotics. Expand
Identification and characterization of novel reptile cathelicidins from elapid snakes
Three cDNA sequences coding for elapid cathelicidins were cloned from constructed venom gland cDNA libraries of Naja atra, Bungarus fasciatus and Ophiophagus hannah and the deduced mature cat helicidin showed strong antibacterial activity against various bacteria with minimal inhibitory concentration of 1-20microg/ml in the presence of 1% NaCl. Expand
Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers
The expression of orthologous cathelicidin genes in the venoms of four different South American pit vipers and an elapid suggests they are a promising template for the development of broad-spectrum peptide antibiotics. Expand
Identification and Functional Characterization of Three Chicken Cathelicidins with Potent Antimicrobial Activity*
The entire chicken genome encodes three cathelicidins, namely fowlicidin-1 to -3, which are densely clustered within a 7.5-kb distance at the proximal end of chromosome 2p, making them excellent candidates for novel antimicrobial and anti-sepsis agents. Expand
Evolution of the avian β-defensin and cathelicidin genes
The phylogenetic and selection analyses on β-defensins and cathelicidins from 53 avian species representing 32 orders have greatly improved the understanding of the molecular evolution of avian AMPs and will be useful to understand their role in the avian innate immune response. Expand
As-CATH1~6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host anti-microbial immune responses.
Six novel cathelicidins from the endangered Chinese Alligator exhibited potent, broad-spectrum and rapid antimicrobial activity by inducing the disruption of cell membrane integrity and inhibited the binding of LPS to TLR4 receptor and the subsequent activation of inflammatory response pathways. Expand
Snake Cathelicidin NA-CATH and Smaller Helical Antimicrobial Peptides Are Effective against Burkholderia thailandensis
It is demonstrated that although B. thailandensis is highly resistant to many antibiotics, cyclic peptide antibiotics such as polymyxin B, and defensing peptides, some antimicrobial peptides including the elapid snake cathelicidin NA-CATH exert significant antimicrobial and antibiofilm activity towards B.Thailandensis. Expand
Novel Cathelicidins from Pigeon Highlights Evolutionary Convergence in Avain Cathelicidins and Functions in Modulation of Innate Immunity
Molecular docking shows for the first time that cathelicidin binds to the opening region of LPS-binding pocket on myeloid differentiation factor 2 of toll-like receptor (TLR)4-MD-2 complex, which in turn inhibits the TLR4 pathway. Expand
Cathelicidin-BF, a Snake Cathelicidin-Derived Antimicrobial Peptide, Could Be an Excellent Therapeutic Agent for Acne Vulgaris
In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium acnes, and its anti-inflammatory effects combined with potent antimicrobial activities and O2− production inhibition activities indicate its potential as a novel therapeutic option for acne vulgaris. Expand