Characterization of a Cannabinoid CB2 Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging

@article{Yao2009CharacterizationOA,
  title={Characterization of a Cannabinoid CB2 Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging},
  author={B. Yao and G. Hsieh and A. Daza and Y. Fan and G. K. Grayson and T. Garrison and Odile F El Kouhen and B. A. Hooker and M. Pai and E. J. Wensink and A. Salyers and P. Chandran and C. Zhu and C. Zhong and K. Ryther and Megan E. Gallagher and C. Chin and A. Tovcimak and V. Hradil and G. Fox and M. Dart and P. Honore and M. Meyer},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2009},
  volume={328},
  pages={141 - 151}
}
  • B. Yao, G. Hsieh, +20 authors M. Meyer
  • Published 2009
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • Studies demonstrating the antihyperalgesic and antiallodynic effects of cannabinoid CB2 receptor activation have been largely derived from the use of receptor-selective ligands. Here, we report the identification of A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], a potent and selective CB2 agonist as characterized in in vitro pharmacological assays and in in vivo models of pain and central nervous system (CNS) behavior… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 44 REFERENCES
    Molecular characterization of a peripheral receptor for cannabinoids
    • 4,127
    Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • 4,330
    Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.
    • 748
    Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.
    • 1,375
    • PDF
    HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor.
    • 488
    • PDF
    CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.
    • 442
    • Highly Influential
    • PDF
    Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.
    • 184