Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons.

@article{Loveland2004CharacterizationOA,
  title={Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons.},
  author={Bruce Edward Loveland and Julie Milland and Panagiota Kyriakou and Bruce R. Thorley and Dale Allen Christiansen and Marc B Lanteri and Mark Regensburg and Maureen S Duffield and Amy J. French and Lindsay F. G. Williams and Louise Leslie Baker and Malcolm Roy Brandon and Pei-xiang Xing and David A. Kahn and Ian Farquhar Campbell Mckenzie},
  journal={Xenotransplantation},
  year={2004},
  volume={11 2},
  pages={
          171-83
        }
}
Human membrane cofactor protein (CD46) controls complement activation and when expressed sufficiently as a transgene protects xenografts against complement-mediated rejection, as shown here using non-immunosuppressed baboons and heterotopic CD46 transgenic pig kidney xenografts. This report is of a carefully engineered transgene that enables high-level CD46 expression. A novel CD46 minigene was validated by transfection and production of a transgenic pig line. Pig lymphocytes were tested for… CONTINUE READING
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