Characterization of a C3a receptor in rainbow trout and Xenopus: the first identification of C3a receptors in nonmammalian species.

@article{Boshra2005CharacterizationOA,
  title={Characterization of a C3a receptor in rainbow trout and Xenopus: the first identification of C3a receptors in nonmammalian species.},
  author={Hani Boshra and Tiehui Wang and Leif Hove-Madsen and John Hansen and Jun Li and Anjun Matlapudi and Christopher J Secombes and L. Anglada Tort and J. Oriol Sunyer},
  journal={Journal of immunology},
  year={2005},
  volume={175 4},
  pages={
          2427-37
        }
}
Virtually nothing is known about the structure, function, and evolutionary origins of the C3aR in nonmammalian species. Because C3aR and C5aR are thought to have arisen from the same common ancestor, the recent characterization of a C5aR in teleost fish implied the presence of a C3aR in this animal group. In this study we report the cloning of a trout cDNA encoding a 364-aa molecule (TC3aR) that shows a high degree of sequence homology and a strong phylogenetic relationship with mammalian C3aRs… CONTINUE READING

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