Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus

@article{Risk2002CharacterizationOA,
  title={Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus},
  author={Janet M. Risk and Kathryn E. Evans and Joanne A Jones and Joanne E. Langan and Lyn Rowbottom and Fiona E Mcronald and Helen S Mills and Anthony J Ellis and Joan M. Shaw and Irene M. Leigh and David P Kelsell and John K. Field},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={6395-6402}
}
The locus for a syndrome of focal palmoplantar keratoderma (Tylosis) associated with squamous cell oesophageal cancer (TOC) has been mapped to chromosome 17q25, a region frequently deleted in sporadic squamous cell oesophageal tumours. Further haplotype analysis described here, based on revised maps of marker order, has reduced the TOC minimal region to a genetic interval of 2 cM limited by the microsatellite markers D17S785 and D17S751. Partial sequence data and complete physical maps estimate… CONTINUE READING
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