Characterization of a [Ca2+]i-dependent current in human atrial and ventricular cardiomyocytes in the absence of Na+ and K+.

@article{Kster1999CharacterizationOA,
  title={Characterization of a [Ca2+]i-dependent current in human atrial and ventricular cardiomyocytes in the absence of Na+ and K+.},
  author={O F K{\"o}ster and Gyula P{\'e}ter Szigeti and Dirk J. Beuckelmann},
  journal={Cardiovascular research},
  year={1999},
  volume={41 1},
  pages={175-87}
}
OBJECTIVES In situations of [Ca2+]i-overload, arrhythmias are believed to be triggered by delayed afterdepolarizations, which are generated by a transient inward current ITI. This study was designed to examine [Ca2+]i-dependent membrane currents in the absence of the Na+/Ca(2+)-exchanger as possible contributors to ITI in human cardiac cells. METHODS The whole cell voltage clamp technique was used for electrophysiological measurements in human atrial and ventricular cardiomyocytes. [Ca2+]i… CONTINUE READING

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