Characterization of XIAP-deficient mice.

  title={Characterization of XIAP-deficient mice.},
  author={Helena Harlin and Stephanie Birkey Reffey and Colin S. Duckett and Tullia Lindsten and Craig B Thompson},
  journal={Molecular and cellular biology},
  volume={21 10},
The inhibitor of apoptosis protein (IAP) family consists of a number of evolutionarily conserved proteins that function to inhibit programmed cell death. X-linked IAP (XIAP) was cloned due to its sequence homology with other family members and has previously been shown to prevent apoptosis by binding to active caspases 3, 7, and 9 in vitro. XIAP transcripts can be found in a variety of tissues, and the protein levels are regulated both transcriptionally and posttranscriptionally. To better… CONTINUE READING
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