Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

@article{Reddy2001CharacterizationOW,
  title={Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis},
  author={Seshamma T Reddy and Thomas Andl and Alexander U Bagasra and Min Min Lu and Douglas J Epstein and Edward E Morrisey and Sarah E. Millar},
  journal={Mechanisms of Development},
  year={2001},
  volume={107},
  pages={69-82}
}
Mutations in WNT effector genes perturb hair follicle morphogenesis, suggesting key roles for WNT proteins in this process. We show that expression of Wnts 10b and 10a is upregulated in placodes at the onset of follicle morphogenesis and in postnatal hair follicles beginning a new cycle of hair growth. The expression of additional Wnt genes is observed in follicles at later stages of differentiation. Among these, we find that Wnt5a is expressed in the developing dermal condensate of wild type… CONTINUE READING
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