Characterization of Volume-Activated Chloride Currents in Regulatory Volume Decrease of Human Cholangiocyte

@article{Chen2010CharacterizationOV,
  title={Characterization of Volume-Activated Chloride Currents in Regulatory Volume Decrease of Human Cholangiocyte},
  author={Biyi Chen and Douglas M. Jefferson and Won Kyoo Cho},
  journal={Journal of Membrane Biology},
  year={2010},
  volume={235},
  pages={17-26}
}
Volume-activated chloride channel (VACC) plays vital roles in many physiological functions. In bile duct epithelium, VACC actively participates in biliary secretion and cell volume regulation, and it mediates regulatory volume decrease (RVD). Recently, we have shown that mouse cholangiocytes have an intact RVD via VACC and K+ conductance. However, such cell volume regulation was not studied in the normal human cholangiocyte. Volume measurement by Coulter counter and whole-cell patch clamp… CONTINUE READING
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