Characterization of Two Novel Retinoic Acid‐resistant Cell Lines Derived from HL‐60 Cells Following Long‐term Culture with all‐trans‐Retinoic Acid

@inproceedings{Mori1999CharacterizationOT,
  title={Characterization of Two Novel Retinoic Acid‐resistant Cell Lines Derived from HL‐60 Cells Following Long‐term Culture with all‐trans‐Retinoic Acid},
  author={Junichirou Mori and Satoru Suzuki and Masahiro Hara and Atsuko Kaneko and Koh Yamashita and Mieko Kumagai and Takahiro Sakuma and Tomoko Kakizawa and Masanori Yamazaki and Teiji Takeda and Takahide Miyamoto and Kazuo Ichikawa and Kiyoshi Hashizume},
  booktitle={Japanese journal of cancer research : Gann},
  year={1999}
}
Either all-trans-retinoic acid (RA) or vitamin D3 (VD) induces differentiation of the myeloid leukemia cell line HL-60. RA is available for the treatment of acute promyeloleukemia, although the development of resistance to the agent is a serious problem for differentiation-inducing therapy. To approach the mechanisms of resistance to RA, we developed two novel cell lines, HL-60-R2 and R9, which were subcloned after exposure to increasing concentrations of RA. The growth rate of HL-60-R2 cells… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Analysis of DNA—general methods

  • M. G. Ormerod
  • “ Flow Cytometry : a Practical Approach
  • 1996

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