Characterization of TcHMGB, a high mobility group B family member protein from Trypanosoma cruzi.

@article{Cribb2011CharacterizationOT,
  title={Characterization of TcHMGB, a high mobility group B family member protein from Trypanosoma cruzi.},
  author={P. Cribb and Marina Perozzi and G. V. Villanova and Andrea Trochine and E. Serra},
  journal={International journal for parasitology},
  year={2011},
  volume={41 11},
  pages={
          1149-56
        }
}
High mobility group B (HMGB) proteins are highly abundant non-histone chromatin proteins that play important roles in the execution and control of many nuclear functions. Based on homology searches, we identified the coding sequence for the TcHMGB protein, an HMGB family member from Trypanosoma cruzi. TcHMGB has two HMG box domains, similar to mammalian HMGBs, but lacks the typical C-terminal acidic tail. Instead, it contains a 110 amino acid long N-terminal domain. The TcHMGB N-terminal domain… Expand
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