Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae.

@article{Williams1990CharacterizationOT,
  title={Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae.},
  author={Fred E. Williams and Robert J Trumbly},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 12},
  pages={6500-11}
}
The TUP1 and CYC8 (= SSN6) genes of Saccharomyces cerevisiae play a major role in glucose repression. Mutations in either TUP1 or CYC8 eliminate or reduce glucose repression of many repressible genes and induce other phenotypes, including flocculence, failure to sporulate, and sterility of MAT alpha cells. The TUP1 gene was isolated in a screen for genes that regulate mating type (V.L. MacKay, Methods Enzymol. 101:325-343, 1983). We found that a 3.5-kb restriction fragment was sufficient for… CONTINUE READING