Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.

@article{Mehra2008CharacterizationOT,
  title={Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.},
  author={Rohit Mehra and Scott Arthur Tomlins and Jianjun Yu and Xuhong Cao and Lei Wang and AJ. Menon and Mark A. Rubin and Rajal B Shah and Arul M. Chinnaiyan},
  journal={Cancer research},
  year={2008},
  volume={68 10},
  pages={
          3584-90
        }
}
Recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS transcription factor family members ERG, ETV1, and ETV4 have been identified as a critical event in prostate cancer development. In this study, we characterized the prevalence and diversity of these rearrangements in hormone-refractory metastatic prostate cancer. We used a fluorescence in situ hybridization (FISH) split probe strategy to comprehensively evaluate TMPRSS2-ETS aberrations across 97 nonosseous metastatic… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 113 CITATIONS, ESTIMATED 53% COVERAGE

217 Citations

01020'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 217 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 23 REFERENCES

Similar Papers

Loading similar papers…