Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1.

@article{Akagi1995CharacterizationOT,
  title={Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1.},
  author={Tsuyoshi Akagi and Hiroaki Ono and Kunitada Shimotohno},
  journal={Blood},
  year={1995},
  volume={86 11},
  pages={4243-9}
}
Peripheral blood T cells were immortalized in vitro by introduction of the Tax1 gene of human T-cell leukemia virus type 1 (HTLV-1) with a retroviral vector and were characterized for transformation-associated markers. Long-term observation showed that these Tax1-immortalized T cells eventually exhibited very similar features that were characteristic of HTLV-1-immortalized T cells, ie, increased expression of egr-1, c-fos, IL-2R alpha, and Lyn and decreased expression of Lck and cell-surface… CONTINUE READING
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