Characterization of Superparamagnetic Nanoparticle Interactions with Extracellular Matrix in an in Vitro System

@article{Kuhn2005CharacterizationOS,
  title={Characterization of Superparamagnetic Nanoparticle Interactions with Extracellular Matrix in an in Vitro System},
  author={Sam J. Kuhn and Dennis E. Hallahan and Todd D Giorgio},
  journal={Annals of Biomedical Engineering},
  year={2005},
  volume={34},
  pages={51-58}
}
Controlled dispersion of therapeutic agents within liquid- and gel-filled cavities represents a barrier to treatment of some cancers and other pathological states. Interstitial delivery is compromised by the poor mobility of macromolecules and larger nanoscale structures. We developed an in vitro system to quantify the suitability of superparamagnetic nanoparticles (SPM NPs) as a site-specific therapeutic vehicle for delivery through fluid- and gel-based systems. SPM NP motion was induced by an… CONTINUE READING
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