Characterization of Structural Features Controlling the Receptiveness of Empty Class II MHC Molecules

@inproceedings{Rupp2011CharacterizationOS,
  title={Characterization of Structural Features Controlling the Receptiveness of Empty Class II MHC Molecules},
  author={Bernd Rupp and Sebastian Guenther and Talat Makhmoor and Andreas Schlundt and Katharina Dickhaut and Shashank Gupta and Iqbal M. Choudhary and Karl-Heinz Wiesmueller and Guenther Jung and Christian Freund and Kirsten Falk and Olaf Roetzschke and Ronald K{\"u}hne},
  booktitle={PloS one},
  year={2011}
}
MHC class II molecules (MHC II) play a pivotal role in the cell-surface presentation of antigens for surveillance by T cells. Antigen loading takes place inside the cell in endosomal compartments and loss of the peptide ligand rapidly leads to the formation of a non-receptive state of the MHC molecule. Non-receptiveness hinders the efficient loading of new antigens onto the empty MHC II. However, the mechanisms driving the formation of the peptide inaccessible state are not well understood… CONTINUE READING
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