Characterization of Saccharomyces cerevisiae thymidylate kinase, the CDC8 gene product. General properties, kinetic analysis, and subcellular localization.

@article{Jong1984CharacterizationOS,
  title={Characterization of Saccharomyces cerevisiae thymidylate kinase, the CDC8 gene product. General properties, kinetic analysis, and subcellular localization.},
  author={Ambrose Y. Jong and Judith L. Campbell},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 23},
  pages={
          14394-8
        }
}
Thymidylate kinase is the product of the CDC8 gene of Saccharomyces cerevisiae (Jong, A.Y.S., Kuo, C.-L., and Campbell, J.L. (1984) J. Biol. Chem. 259, 11052-11059). In this communication we report the catalytic properties of the enzyme. The enzyme catalyzes the phosphorylation of deoxythymidine monophosphate to form deoxythymidine diphosphate in the presence of phosphate donor. ATP and dATP are the most efficient phosphate donors. In addition to dTMP, the yeast enzyme can use dUMP and 5-iodo… CONTINUE READING

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