Characterization of STZ-Induced Type 2 Diabetes in Zucker Fatty Rats.

@article{Okamoto2008CharacterizationOS,
  title={Characterization of STZ-Induced Type 2 Diabetes in Zucker Fatty Rats.},
  author={Tetsugaku Okamoto and Naohide Kanemoto and Yutaka Ohbuchi and Mai Okano and Hiroyuki Fukui and Toshiki Sudo},
  journal={Experimental animals},
  year={2008},
  volume={57 4},
  pages={
          335-45
        }
}
The Zucker fatty (ZF) rat is a disease model of obesity and metabolic syndrome, such as hyperlipidemia and insulin resistance, resulting from hyperphagia owing to the loss of function of the leptin receptor, but it rarely develops hyperglycemia. We examined the effects of different doses of streptozotocin (STZ). A low dosage of STZ (30 mg/kg body weight, i.p.) elevated blood glucose levels in ZF rats up to 300 mg/dl within a week, and to nearly 500 mg/dl by 5 weeks after injection of STZ… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Small mammalian animal models of heart disease.

  • American journal of cardiovascular disease
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Combination of high fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and parmacological screening

K. Srinvansan, B. Viswanad, L. Asrat, C. L. Kaul, P. Ramarao
  • Pharmacol. Res
  • 2005
VIEW 2 EXCERPTS