Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis

@inproceedings{Brnnstrm2012CharacterizationOS,
  title={Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis},
  author={K. Br{\"a}nnstr{\"o}m and Anders Öhman and Ulrich von Pawel Rammingen and A. Olofsson and M. Brattsand},
  booktitle={Biological chemistry},
  year={2012}
}
Abstract SPINK9, a Kazal-type serine protease inhibitor, is almost exclusively expressed in the palmo-plantar epidermis. SPINK9 selectively inhibits kallikrein-related peptidase 5 (KLK5), no other target enzyme is known at present. In this study, we defined the reactive loop to residues 48 and 49 of SPINK9 and characterized the inhibition and binding of different SPINK9 variants towards KLK5, KLK7, KLK8 and KLK14. Substitutions of single amino acids in the reactive loop had a large impact on… Expand
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Skin-Derived SPINK9 Kills Escherichia coli.
Kallikrein-Related Peptidase 8 (KLK8): The Structure and Function in the Epidermis
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