# Characterization of SNPs in the dopamine-β-hydroxylase gene providing new insights into its structure-function relationship

@article{Punchaichira2017CharacterizationOS,
title={Characterization of SNPs in the dopamine-$\beta$-hydroxylase gene providing new insights into its structure-function relationship},
author={Toyanji Joseph Punchaichira and Sanjay Kumar Dey and Anirban Mukhopadhyay and Suman Kundu and B. K. Thelma},
journal={neurogenetics},
year={2017},
volume={18},
pages={155-168}
}
• Published 1 July 2017
• Biology
• neurogenetics
Dopamine-β-hydroxylase (DBH, EC 1.14.17.1), an oxido-reductase that catalyses the conversion of dopamine to norepinephrine, is largely expressed in sympathetic neurons and adrenal medulla. [] Key Method The DBH ORF with wild type (WT) and site-directed mutagenized variants were transfected into HEK293 cells to generate transient and stable lines expressing these variant enzymes.

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