Characterization of SNARE protein expression in beta cell lines and pancreatic islets.

@article{Wheeler1996CharacterizationOS,
  title={Characterization of SNARE protein expression in beta cell lines and pancreatic islets.},
  author={Michael B Wheeler and Laura Sheu and Mala Ghai and A I Bouquillon and Gilles Grondin and Ulrich Weller and Adrien R. Beaudoin and M. K. Bennett and William S. Trimble and Herbert Y Gaisano},
  journal={Endocrinology},
  year={1996},
  volume={137 4},
  pages={1340-8}
}
Pancreatic beta cells and cell lines were used in the present study to test the hypothesis that the molecular mechanisms controlling exocytosis from neuronal cells may be used by the beta cell to regulate insulin secretion. Using specific antisera raised against an array of synaptic proteins (SNAREs) implicated in the control of synaptic vesicle fusion and exocytosis, we have identified the expression of several SNAREs in the islet beta cell lines, beta TC6-f7 and HIT-T15, as well as in… CONTINUE READING

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