Characterization of SENP7, a SUMO-2/3-specific isopeptidase.

  title={Characterization of SENP7, a SUMO-2/3-specific isopeptidase.},
  author={L. N. Shen and Marie-Claude Geoffroy and E. Jaffray and R. Hay},
  journal={The Biochemical journal},
  volume={421 2},
  • L. N. Shen, Marie-Claude Geoffroy, +1 author R. Hay
  • Published 2009
  • Biology, Medicine
  • The Biochemical journal
  • The modification of proteins by SUMO (small ubiquitin-related modifier) plays important roles in regulating the activity, stability and cellular localization of target proteins. Similar to ubiquitination, SUMO modification is a dynamic process that can be reversed by SENPs [SUMO-1/sentrin/SMT3 (suppressor of mif two 3 homologue 1)-specific peptidases]. To date, six SENPs have been discovered in humans, although knowledge of their regulation, specificity and biological functions is limited. In… CONTINUE READING
    88 Citations
    Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases.
    • 16
    • PDF
    Distribution and paralogue specificity of mammalian deSUMOylating enzymes.
    • 83
    • PDF
    SUMO-specific proteases and isopeptidases of the SENP family at a glance
    • 53
    • Highly Influenced
    • PDF
    Important role of SUMOylation of Spliceosome factors in prostate cancer cells.
    • 42
    Swapping Small Ubiquitin-like Modifier (SUMO) Isoform Specificity of SUMO Proteases SENP6 and SENP7*
    • 20
    • PDF
    Decoding the SUMO signal.
    • R. Hay
    • Biology, Medicine
    • Biochemical Society transactions
    • 2013
    • 91


    Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3*
    • 219
    • PDF
    Small Ubiquitin-related Modifier (SUMO)-specific Proteases
    • 131
    • PDF
    SUMO protease SENP1 induces isomerization of the scissile peptide bond
    • 96
    • PDF
    Modification in reverse: the SUMO proteases.
    • 493
    SUSP1 antagonizes formation of highly SUMO2/3-conjugated species
    • 148
    • PDF
    Differential Regulation of Sentrinized Proteins by a Novel Sentrin-specific Protease*
    • 277
    • PDF