Characterization of SENP7, a SUMO-2/3-specific isopeptidase.

@article{Shen2009CharacterizationOS,
  title={Characterization of SENP7, a SUMO-2/3-specific isopeptidase.},
  author={L. N. Shen and Marie-Claude Geoffroy and E. Jaffray and R. Hay},
  journal={The Biochemical journal},
  year={2009},
  volume={421 2},
  pages={
          223-30
        }
}
  • L. N. Shen, Marie-Claude Geoffroy, +1 author R. Hay
  • Published 2009
  • Biology, Medicine
  • The Biochemical journal
  • The modification of proteins by SUMO (small ubiquitin-related modifier) plays important roles in regulating the activity, stability and cellular localization of target proteins. Similar to ubiquitination, SUMO modification is a dynamic process that can be reversed by SENPs [SUMO-1/sentrin/SMT3 (suppressor of mif two 3 homologue 1)-specific peptidases]. To date, six SENPs have been discovered in humans, although knowledge of their regulation, specificity and biological functions is limited. In… CONTINUE READING
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    References

    SHOWING 1-10 OF 38 REFERENCES
    Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3*
    • 219
    • PDF
    Small Ubiquitin-related Modifier (SUMO)-specific Proteases
    • 131
    • PDF
    SUMO protease SENP1 induces isomerization of the scissile peptide bond
    • 96
    • PDF
    Modification in reverse: the SUMO proteases.
    • 493
    SUSP1 antagonizes formation of highly SUMO2/3-conjugated species
    • 148
    • PDF
    Differential Regulation of Sentrinized Proteins by a Novel Sentrin-specific Protease*
    • 277
    • PDF