Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes.

@article{Vosse1998CharacterizationOS,
  title={Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes.},
  author={Esther van de Vosse and Susannah M. Walpole and Anna Nicolaou and Paola van der Bent and Anthony P. Cahn and Mark Vaudin and Mark T. Ross and Jillian Durham and Rebecca Pavitt and Jane Wilkinson and Darren Grafham and Arthur A. B. Bergen and Gertjan JB van Ommen and John R. Yates and Johan T den Dunnen and Dorothy Trump},
  journal={Genomics},
  year={1998},
  volume={49 1},
  pages={96-102}
}
Using exon trapping, we have identified a new human gene in Xp22 encoding a 3-kb mRNA. Expression of this RNA is detectable in a range of tissues but is most pronounced in skeletal muscle and heart. The gene, designated "sex comb on midleg-like-1" (SCML1), maps 14 kb centromeric of marker DXS418, between DXS418 and DXS7994, and is transcribed from telomere to centromere. SCML1 spans 18 kb of genomic DNA, consists of six exons, and has a 624-bp open reading frame. The predicted 27-kDa SCML1… CONTINUE READING
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