Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis.

@article{Liu2013CharacterizationOS,
  title={Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis.},
  author={Yanping Liu and Tingting Yan and Libin Jiang and Ying Wen and Yuan Song and Zhi Chen and Jilun Li},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 19},
  pages={
          4365-72
        }
}
The role of a tetR transcriptional regulatory gene (SAV7471) in avermectin production in the Gram-positive soil bacterium Streptomyces avermitilis was investigated by gene deletion, complementation, and overexpression experiments. Gene deletion of the SAV7471 open reading frame resulted in avermectin overproduction. The deletion also resulted in overexpression of SAV7472-SAV7473 transcripts, which encode a protein of unknown function and a flavoprotein possibly involved in pantothenate and… CONTINUE READING

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