Characterization of RyR1-slow, a ryanodine receptor specific to slow-twitch skeletal muscle.

@article{Morrissette2000CharacterizationOR,
  title={Characterization of RyR1-slow, a ryanodine receptor specific to slow-twitch skeletal muscle.},
  author={Joel Morrissette and Ling Xu and Aaron Nelson and Gerhard Meissner and Barbara A Block},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={279 5},
  pages={R1889-98}
}
Two distinct skeletal muscle ryanodine receptors (RyR1s) are expressed in a fiber type-specific manner in fish skeletal muscle (11). In this study, we compare [(3)H]ryanodine binding and single channel activity of RyR1-slow from fish slow-twitch skeletal muscle with RyR1-fast and RyR3 isolated from fast-twitch skeletal muscle. Scatchard plots indicate that RyR1-slow has a lower affinity for [(3)H]ryanodine when compared with RyR1-fast. In single channel recordings, RyR1-slow and RyR1-fast had… CONTINUE READING
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