Characterization of RhoA-mediated chemoresistance in gastric cancer cells.

  title={Characterization of RhoA-mediated chemoresistance in gastric cancer cells.},
  author={Gyeong Hoon Kang and Inkyoung Lee and Chaehwa Park},
  journal={Cancer research and treatment : official journal of Korean Cancer Association},
  volume={37 4},
PURPOSE RhoA is a critical transducer of extracellular signals, which leads to organization of actin cytoskeleton, motility, adhesion and gene regulation. The present study aimed to explore whether RhoA influences the susceptibility of gastric cancer cells to chemotherapeutic drugs. MATERIALS AND METHODS SNU638 cells were transfected with a mock vector (pcDNA3.1), RhoA (pcDNA/RhoA), or constitutively active RhoA (pcDNA/caRhoA). MTT assay and Western blot analysis were performed to study the… CONTINUE READING