Characterization of Retinal Vascular and Neural Damage in a Novel Model of Diabetic Retinopathy.

@article{Weerasekera2015CharacterizationOR,
  title={Characterization of Retinal Vascular and Neural Damage in a Novel Model of Diabetic Retinopathy.},
  author={Lakshini Y Weerasekera and Lois Balmer and Ramesh Ram and Grant Morahan},
  journal={Investigative ophthalmology \& visual science},
  year={2015},
  volume={56 6},
  pages={
          3721-30
        }
}
PURPOSE Diabetic retinopathy (DR) is a major cause of blindness globally. Investigating the underlying mechanisms of DR would be aided by a suitable mouse model that developed key features seen in the human disease, and did so without carrying genetic modifications. This study was undertaken to produce such a model. METHODS Our panel of Collaborative Cross strains was screened for DR-like features after induction of diabetes by intravenous injection with alloxan or streptozotocin. Both flat… 
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