Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling.

@article{Rodriguez2006CharacterizationOR,
  title={Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling.},
  author={Nelson Nu{\~n}ez Rodriguez and Ivy N L Lee and Asoka Banno and Hui Qiao and Rui Fang Qiao and Zhong Yao and Thuong Hoang and Alec C. Kimmelman and Andrew M-L Chan},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 19},
  pages={7145-54}
}
R-Ras3/M-Ras is a member of the RAS superfamily of small-molecular-weight GTP-binding proteins. Previous studies have demonstrated high levels of expression in several regions of the central nervous system, and a constitutively active form of M-Ras promotes cytoskeletal reorganization, cellular transformation, survival, and differentiation. However, the physiological functions of M-Ras during embryogenesis and postnatal development have not been elucidated. By using a specific M-Ras antibody… CONTINUE READING

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