Characterization of Puumala virus nucleocapsid protein: identification of B-cell epitopes and domains involved in protective immunity.

@article{Lundkvist1996CharacterizationOP,
  title={Characterization of Puumala virus nucleocapsid protein: identification of B-cell epitopes and domains involved in protective immunity.},
  author={{\AA}ke Lundkvist and Hannimari Kallio-Kokko and Katarina Brus Sj{\"o}lander and Hilkka Lankinen and B H Niklasson and Antti Vaheri and Olli Vapalahti},
  journal={Virology},
  year={1996},
  volume={216 2},
  pages={397-406}
}
B-cell epitopes in the nucleocapsid protein (N) of Puumala (PUU) virus were investigated by use of truncated recombinant proteins and overlapping peptides. Six of seven epitopes, recognized by bank vole monoclonal antibodies, were localized within the amino-terminal region of the protein (aa 1-79). Polyclonal antibodies from wild-trapped or experimentally infected bank voles identified epitopes located over the entire protein. Antibody end-point titers to different N fragments indicated that… CONTINUE READING

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