Characterization of Promoter Elements Regulating the Expression of the Human Neurotensin/Neuromedin N Gene*

@article{Wang2010CharacterizationOP,
  title={Characterization of Promoter Elements Regulating the Expression of the Human Neurotensin/Neuromedin N Gene*},
  author={X. Wang and Pat Gulhati and J. Li and P. Dobner and H. Weiss and C. Townsend and B. Evers},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={286},
  pages={542 - 554}
}
Expression of the gene encoding neurotensin/neuromedin N (NT/N) is mostly limited to the brain and specialized enteroendocrine N cells in the distal small intestine. We have identified key regulatory elements in the promoter region that are involved in human NT/N (hNT/N) gene expression in the novel human endocrine cell line, BON, which resembles intestinal N cells in several important aspects including NT/N precursor protein processing, ratios of different NT/N mRNA isoforms, and high levels… Expand
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