Characterization of PaxA and its operon: a cohemolytic RTX toxin determinant from pathogenic Pasteurella aerogenes.

@article{Kuhnert2000CharacterizationOP,
  title={Characterization of PaxA and its operon: a cohemolytic RTX toxin determinant from pathogenic Pasteurella aerogenes.},
  author={Peter Kuhnert and Benedicte Heyberger-Meyer and Jacques Nicolet and Joachim Frey},
  journal={Infection and immunity},
  year={2000},
  volume={68 1},
  pages={6-12}
}
Pasteurella aerogenes is known as a commensal bacterium or as an opportunistic pathogen, as well as a primary pathogen found to be involved in abortion cases of humans, swine, and other mammals. Using broad-range DNA probes for bacterial RTX toxin genes, we cloned and subsequently sequenced a new operon named paxCABD encoding the RTX toxin PaxA in P. aerogenes. The pax operon is organized analogous to the classical RTX operons containing the activator gene paxC upstream of the structural toxin… CONTINUE READING
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