Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization

Abstract

PTEN is a PIP3 phosphatase that antagonizes oncogenic PI3-kinase signalling. Due to its critical role in suppressing the potent signalling pathway, it is one of the most mutated tumour suppressors, especially in brain tumours. It is generally thought that PTEN deficiencies predominantly result from either loss of expression or enzymatic activity. By… (More)
DOI: 10.1038/onc.2016.493

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Cite this paper

@inproceedings{Yang2017CharacterizationOP, title={Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization}, author={J -Y Yang and Paula Schiapparelli and H Nguyen and Atsunobu Igarashi and Qi’an Zhang and Sara Abbadi and L Mario Amzel and Hiromi Sesaki and Alfredo Quinones-Hinojosa and Miho Iijima}, booktitle={Oncogene}, year={2017} }