Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus.

  title={Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus.},
  author={Asm{\`a}a Bouayad and Hiroki Kajino and Nahid Waleh and J C Fouron and Gregor U. Andelfinger and D. Ramesh Varma and Amanda Skoll and Adrinel V{\'a}zquez and François Gobeil and Ronald I. Clyman and Sylvain Chemtob},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={280 5},
Although the role of PGE2 in maintaining ductus arteriosus (DA) patency is well established, the specific PGE2 receptor subtype(s) (EP) involved have not been clearly identified. We used late gestation fetal and neonatal lambs to study developmental regulation of EP receptors. In the fetal DA, radioligand binding and RT-PCR assays virtually failed to detect EP1 but detected EP2, EP3D, and EP4 receptors in equivalent proportions. In the newborn lamb, DA total density was one-third of that found… CONTINUE READING
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