Characterization of PDZ-binding kinase, a mitotic kinase.

@article{Gaudet2000CharacterizationOP,
  title={Characterization of PDZ-binding kinase, a mitotic kinase.},
  author={Suzanne Gaudet and Daniel Branton and Robert A. Lue},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 10},
  pages={5167-72}
}
hDlg, the human homologue of the Drosophila Discs-large (Dlg) tumor suppressor protein, is known to interact with the tumor suppressor protein APC and the human papillomavirus E6 transforming protein. In a two-hybrid screen, we identified a 322-aa serine/threonine kinase that binds to the PDZ2 domain of hDlg. The mRNA for this PDZ-binding kinase, or PBK, is most abundant in placenta and absent from adult brain tissue. The protein sequence of PBK has all the characteristic protein kinase… CONTINUE READING
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Molecular Cloning: A Laboratory Manual (Cold

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