Characterization of OXA-29 from Legionella (Fluoribacter) gormanii: molecular class D beta-lactamase with unusual properties.

@article{Franceschini2001CharacterizationOO,
  title={Characterization of OXA-29 from Legionella (Fluoribacter) gormanii: molecular class D beta-lactamase with unusual properties.},
  author={Nicola Franceschini and Letizia Boschi and Simona Pollini and Rapha{\"e}l Herman and Mariagrazia Perilli and Moreno Galleni and Jean Marie Fr{\`e}re and Gianfranco Amicosante and Gian Maria Rossolini},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 12},
  pages={3509-16}
}
A class D beta-lactamase determinant was isolated from the genome of Legionella (Fluoribacter) gormanii ATCC 33297(T). The enzyme, named OXA-29, is quite divergent from other class D beta-lactamases, being more similar (33 to 43% amino acid identity) to those of groups III (OXA-1) and IV (OXA-9, OXA-12, OXA-18, and OXA-22) than to other class D enzymes (21 to 24% sequence identity). Phylogenetic analysis confirmed the closer ancestry of OXA-29 with members of the former groups. The OXA-29… CONTINUE READING

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