Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

@inproceedings{Heikkinen2012CharacterizationON,
  title={Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease},
  author={Taneli Heikkinen and Kimmo K. Lehtim{\"a}ki and Nina E Vartiainen and Jukka T. Puoliv{\"a}li and Susan J. Hendricks and Jack R. Glaser and Amyaouch Bradaia and Kristian Wadel and Chrystelle Touller and Outi Kontkanen and Juha M. Yrj{\"a}nheikki and Bruno Buisson and David Howland and Vahri Beaumont and Ignacio Mu{\~n}oz-Sanju{\'a}n and Larry C H Park},
  booktitle={PloS one},
  year={2012}
}
Huntington's disease (HD) is an autosomal neurodegenerative disorder, characterized by severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene (HTT) mutation that causes the disease, several mouse lines have been developed using different gene constructs of Htt. Recently, a new model, the zQ175 knock-in (KI) mouse, was developed (see description by Menalled et al, [1]) in an attempt to have the Htt gene in a context and causing a phenotype that more closely… CONTINUE READING
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