Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.

@article{Doi2012CharacterizationON,
  title={Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.},
  author={Colleen L. Doçi and Tanmayi Pradeep Mankame and Alexander J. Langerman and Kelly R. Ostler and Rajani Kanteti and Timothy F. Best and Kenan Onel and Lucy A Godley and Ravi Salgia and Mark W. Lingen},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={2012},
  volume={31 1},
  pages={
          15-24
        }
}
NOL7 is a putative tumor suppressor gene localized to 6p23, a region with frequent loss of heterozygosity in a number of cancers, including cervical cancer (CC). We have previously demonstrated that reintroduction of NOL7 into CC cells altered the angiogenic phenotype and suppressed tumor growth in vivo by 95%. Therefore, to understand its mechanism of inactivation in CC, we investigated the genetic and epigenetic regulation of NOL7. NOL7 mRNA and protein levels were assessed in 13 CC cell… CONTINUE READING
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