Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis

@inproceedings{Allen2013CharacterizationON,
  title={Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis},
  author={Irving C Allen and Erin McElvania-Tekippe and Justin E. Wilson and John D. Lich and Janelle C Arthur and Jonathan Tabb Sullivan and Miriam Braunstein and Jenny P-Y Ting},
  booktitle={PloS one},
  year={2013}
}
The majority of nucleotide binding domain leucine rich repeats-containing (NLR) family members has yet to be functionally characterized. Of the described NLRs, most are considered to be proinflammatory and facilitate IL-1β production. However, a newly defined sub-group of NLRs that function as negative regulators of inflammation have been identified based on their abilities to attenuate NF-κB signaling. NLRP12 (Monarch-1) is a prototypical member of this sub-group that negatively regulates both… CONTINUE READING
22 Citations
53 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

NLRP12 Functions as a Negative Regulator of Noncanonical NF-kB Signaling and Tumorigenesis during Colitis Associated Cancer

  • IC Allen, JE Wilson, M Schneider, JD Lich, JC Authur
  • Immunity . May 25
  • 2012
Highly Influential
8 Excerpts

NLRC 3 Attenuates TLR Signaling via Modification of TRAF 6 and NFk B . Nature Immunology

  • M Schneider, AG Zimmermann, R Roberts, L Zhang, KV Swanson
  • 2012

Similar Papers

Loading similar papers…