Characterization of NKT cells in human peripheral blood and decidual lymphocytes.

  title={Characterization of NKT cells in human peripheral blood and decidual lymphocytes.},
  author={Hiroshi Tsuda and Masatoshi Sakai and Toshihiko Michimata and Kyoko Tanebe and Satoshi Hayakawa and Shigeru Saito},
  journal={American journal of reproductive immunology},
  volume={45 5},
PROBLEM To examine whether natural killer (NKT) cells are present in human pregnancy decidua. METHOD OF STUDY We calculated the percentage of CD3+CD161+Valpha 24+-NKT cells in peripheral blood and early pregnancy decidua, and analyzed intracellular cytokines, interleukin (IL)-4 and interferon (IFN)gamma in NKT cells using flow cytometry. RESULTS A distinct subset of CD3+ CD161+ lymphocytes expressing an invariant antigen receptor encoded by the Valpha24 and Vbeta11 segment was accumulated… CONTINUE READING

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