Characterization of NE81, the first lamin-like nucleoskeleton protein in a unicellular organism

@inproceedings{Krger2012CharacterizationON,
  title={Characterization of NE81, the first lamin-like nucleoskeleton protein in a unicellular organism},
  author={Anne Kr{\"u}ger and Petros Batsios and Otto Baumann and Eva Luckert and Heinz J. Schwarz and Reimer Stick and Irene C. Meyer and Ralph O Gr{\"a}f},
  booktitle={Molecular biology of the cell},
  year={2012}
}
Lamins build the nuclear lamina and are required for chromatin organization, gene expression, cell cycle progression, and mechanical stabilization. Despite these universal functions, lamins have so far been found only in metazoans. We have identified protein NE81 in Dictyostelium, which has properties that justify its denomination as a lamin-like protein in a lower eukaryote. This is based on its primary structure, subcellular localization, and regulation during mitosis, and its requirement of… CONTINUE READING
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