Characterization of N-linked oligosaccharides of an HLA-DR molecule expressed in different cell lines.

@article{Neel1987CharacterizationON,
  title={Characterization of N-linked oligosaccharides of an HLA-DR molecule expressed in different cell lines.},
  author={D. Neel and Benoit Merlu and Elisabeth Turpin and Chantal Rabourdin-Combe and Bernard Mach and Yves Goussault and Dominique J. Charron},
  journal={The Biochemical journal},
  year={1987},
  volume={244 2},
  pages={
          433-42
        }
}
In order to determine the factors that influence the glycosylation of an integral membrane protein, we investigated the N-glycosylation of a molecule of the human major histocompatibility complex (MHC) class II, the HLA-DR antigen. This glycoprotein was studied in a human Epstein-Barr-virus-transformed B cell line and in a mouse fibroblastic cell line co-transfected with DR alpha and DR beta genes. We observed that the HLA-DR-antigen glycosylation pattern depends on the cell line in which… CONTINUE READING
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