Characterization of MspA, an immunogenic autotransporter protein that mediates adhesion to epithelial and endothelial cells in Neisseria meningitidis.

@article{Turner2006CharacterizationOM,
  title={Characterization of MspA, an immunogenic autotransporter protein that mediates adhesion to epithelial and endothelial cells in Neisseria meningitidis.},
  author={David P. J. Turner and Angeliki Marietou and Leslie Johnston and Krystina L. Ho and Andrew John Rogers and Karl G. Wooldridge and Dlawer A A Ala'aldeen},
  journal={Infection and immunity},
  year={2006},
  volume={74 5},
  pages={
          2957-64
        }
}
A novel putative autotransporter protein (NMB1998) was identified in the available genomic sequence of meningococcal strain MC58 (ET-5; ST-32). The mspA gene is absent from the genomic sequences of meningococcal strain Z2491 (ET-IV; ST-4) and the gonococcal strain FA1090. An orthologue is present in the meningococcal strain FAM18 (ET-37; ST-11), but the sequence contains a premature stop codon, suggesting that the protein may not be expressed in this strain. MspA is predicted to be a 157-kDa… CONTINUE READING
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