Characterization of Mouse Embryonic Cells Deficient in the Ctr1 High Affinity Copper Transporter

  title={Characterization of Mouse Embryonic Cells Deficient in the Ctr1 High Affinity Copper Transporter},
  author={J. Lee and M. Petris and D. J. Thiele},
  journal={The Journal of Biological Chemistry},
  pages={40253 - 40259}
  • J. Lee, M. Petris, D. J. Thiele
  • Published 2002
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • The trace metal copper is an essential cofactor for a number of enzymes that have critical roles in biological processes, but it is highly toxic when allowed to accumulate in excess of cellular needs. Consequently, homeostatic copper metabolism is maintained by molecules involved in copper uptake, distribution, excretion, and incorporation into copper-requiring enzymes. Previously, we reported that overexpression of the human or mouse Ctr1 copper transporter stimulates copper uptake in… CONTINUE READING
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