Characterization of Mouse Embryonic Cells Deficient in the Ctr1 High Affinity Copper Transporter

@article{Lee2002CharacterizationOM,
  title={Characterization of Mouse Embryonic Cells Deficient in the Ctr1 High Affinity Copper Transporter},
  author={J. Lee and M. Petris and D. J. Thiele},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={40253 - 40259}
}
  • J. Lee, M. Petris, D. J. Thiele
  • Published 2002
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • The trace metal copper is an essential cofactor for a number of enzymes that have critical roles in biological processes, but it is highly toxic when allowed to accumulate in excess of cellular needs. Consequently, homeostatic copper metabolism is maintained by molecules involved in copper uptake, distribution, excretion, and incorporation into copper-requiring enzymes. Previously, we reported that overexpression of the human or mouse Ctr1 copper transporter stimulates copper uptake in… CONTINUE READING
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    References

    SHOWING 1-10 OF 45 REFERENCES
    Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development
    • 387
    • PDF
    The copper transporter CTR1 provides an essential function in mammalian embryonic development
    • 320
    • PDF
    hCTR1: a human gene for copper uptake identified by complementation in yeast.
    • B. Zhou, J. Gitschier
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1997
    • 516
    • PDF
    Characterization of the Saccharomyces cerevisiae High Affinity Copper Transporter Ctr3*
    • 170
    • PDF
    The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis
    • 180
    • PDF
    A delicate balance: homeostatic control of copper uptake and distribution.
    • 646
    • PDF