Characterization of MgtC, a Virulence Factor of Salmonella enterica Serovar Typhi

@article{Retamal2009CharacterizationOM,
  title={Characterization of MgtC, a Virulence Factor of Salmonella enterica Serovar Typhi},
  author={Patricio Retamal and Mario Castillo-Ruiz and Guido C. Mora},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={998 - 1004}
}
The MgtC is a virulence factor in Salmonella Typhimurium that is required for growth at low-Mg2+ concentrations and intramacrophage survival. This gene is codified in a conserved region of the Salmonella pathogenicity island 3 (SPI-3), and is also present in the chromosome of other Salmonella serovars. In this study we characterized the MgtC factor in S. Typhi, a human specific pathogen, by using mgtC and SPI-3 mutant strains. We found that MgtC is the most important factor codified in the SPI… CONTINUE READING

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